Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating AMPK improves pathological phenotypes due to mtDNA depletion.

The FEBS journal - 1 May 2025

Carvalho Gustavo, Nguyen Tran V H, Repolês Bruno, Forslund Josefin M E, Wijethunga W M Ruchitha Rukmal, Ranjbarian Farahnaz, Mendes Isabela C, Gorospe Choco Michael, Chaudhari Namrata, Falabella Micol, Doimo Mara, Wanrooij Sjoerd, Pitceathly Robert D S, Hofer Anders, Wanrooij Paulina H

Abstract excerpt

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis that also plays a role in preserving mitochondrial function and integrity. Upon a disturbance in the cellular energy state that increases AMP levels, AMPK activity promotes a switch from anabolic to catabolic metabolism to restore energy homeostasis. However, the level of severity of mitochondrial dysfunction required to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biphenyl Compounds

Share to Enzyme Activation

Share to Membrane Potential, Mitochondrial

Share to Mitochondrial Diseases

Share to Pyrones

Share to Thiophenes

Source

Open in PubMed Open full text

Identifiers

PMID: 39918244
DOI: 10.1111/febs.70006
PMCID: PMC12062783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating AMPK improves pathological phenotypes due to mtDNA depletion.PMID 39918244Read ↗

The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletionSemantic proximity Read ↗

AMPK is mitochondrial medicine for neuromuscular disordersSemantic proximity Read ↗

Identification and small molecule rescue of mitochondrial dysfunction phenotype which converges across Leigh Syndrome and Huntington’s Disease patient fibroblastsSemantic proximity Read ↗

Regulation of mitochondrial biogenesisSemantic proximity Read ↗

Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial diseaseSemantic proximity Read ↗

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.Semantic proximity Read ↗

Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological TherapiesSemantic proximity Read ↗

Pharmacological activation of AMPK rescues mitophagy defects in models of FBXL4-related mitochondrial DNA depletion syndromeSemantic proximity Read ↗

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read ↗

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells.Semantic proximity Read ↗

Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation.Semantic proximity Read ↗

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.