Article

The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion

2024-03-14

Abstract excerpt

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis that also plays a role in preserving mitochondrial function and integrity. Upon a disturbance in the cellular energy state that increases AMP levels, AMPK activity promotes a switch from anabolic to catabolic metabolism to restore energy homeostasis. However, it is currently unclear how severe of a mitochondrial dysfunction is...

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Literature Corpus work: 98cddb84-bcfb-52ec-bf9b-46dcd5aab665
DOI: 10.1101/2024.03.14.584413

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