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Article

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Rieck Mary, Arechiga Adrian, Onengut-Gumuscu Suna, Greenbaum Carla, Concannon Patrick, Buckner Jane H

Abstract excerpt

A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for the development of a wide array of autoimmune disorders. It is known that the protein tyrosine phosphatase Lyp encoded by this gene has an inhibitory effect on the proximal TCR signaling pathways. However, the consequ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17878369
DOI: 10.4049/jimmunol.179.7.4704

Genes

PTPN22
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878369-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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