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Article

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells

16 Oct 2009

Abstract excerpt

TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease patients. Neutralizing anti-mouse TL1A Ab attenuates chronic colitis in two T-cell driven murine models, suggesting that TL1A is a central modulator of gut mucosal inflammation in inflammatory bowel disease. We showed previously that TL1A is induced by immune complexes via the Fc gamma R signaling...

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PMID: 19839006
DOI: 10.1002/eji.200839087

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