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Article

Polymorphisms in the tumor necrosis factor/lipopolysaccharides pathway in Crohn disease in the Jewish Ashkenazi population.

Journal of pediatric gastroenterology and nutrition - 1 May 2008

Silbermintz Ari, Levine Jeremiah, Weinstein Toba, Silver Jack

Abstract excerpt

OBJECTIVE: Tumor necrosis factor (TNF)-alpha plays a role in the inflammatory process in Crohn disease, a disease with an apparent polygenic basis. We investigated whether polymorphisms in multiple genes involved in the lipopolysaccharide-TNF inflammatory pathway are independently associated with Crohn disease in the Jewish Ashkenazi population. Polymorphisms in CD14, Toll-like receptor 4 (TLR4), and TNF-alpha...

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Source

Identifiers

PMID: 18493210
DOI: 10.1097/MPG.0b013e3181653ab5

Genes

TNF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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