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Article

CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease.

The American journal of gastroenterology - 1 Feb 2004

Newman Bill, Silverberg Mark S, Gu Xiangjun, Zhang Qing, Lazaro Ana, Steinhart A Hillary, Greenberg Gordon R, Griffiths Anne M, McLeod Robin S, Cohen Zane, Fernández-Viña Marcelo, Amos Christopher I, Siminovitch Katherine

Abstract excerpt

OBJECTIVES: Crohn's disease (CD) is a chronic inflammatory disease of the gut associated with allelic variants of CARD15 and HLA-DRB1 genes. We investigated the prevalence and effects of these variants in a Canadian CD cohort. METHODS: 507 unrelated CD patients were genotyped for the three major CD-associated variants (Arg702Trp, Gly908Arg, and Leu1007fsinsC) and for thirteen HLA-DRB1 alleles. RESULTS: At least...

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PMID: 15046222
DOI: 10.1111/j.1572-0241.2004.04038.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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