Article
Type 1 diabetes genes and pathways shared by humans and NOD mice.
Journal of autoimmunity - 1 Jan 2005
Wicker Linda S, Clark Jan, Fraser Heather I, Garner Valerie E S, Gonzalez-Munoz Andrea, Healy Barry, Howlett Sarah, Hunter Kara, Rainbow Dan, Rosa Raymond L, Smink Luc J, Todd John A, Peterson Laurence B
Abstract excerpt
The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in humans and candidate genes in the NOD mouse has made significant progress in recent years. In addition to sharing structural aspects of the MHC class II molecules that confer susceptibility or resistance to T1D, genes and pathways contributing to autoimmune pathogenesis are held in common by the two species. There are data...
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