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Article

Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Wang Jian, Yoshida Taku, Nakaki Fumio, Hiai Hiroshi, Okazaki Taku, Honjo Tasuku

Abstract excerpt

Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously develop lupus-like autoimmune disease and autoimmune dilated cardiomyopathy on C57BL/6 and BALB/c backgrounds, respectively. However, how PD-1 deficiency induces different forms of autoimmune diseases on these two strains was unknown. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16087865
DOI: 10.1073/pnas.0505497102
PMCID: PMC1188011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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