Article
The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study.
BMC medical genetics - 27 Feb 2009
Andersen Vibeke, Agerstjerne Lene, Jensen Dorte, Østergaard Mette, Saebø Mona, Hamfjord Julian, Kure Elin, Vogel Ulla
Abstract excerpt
BACKGROUND: Smoking, dietary factors, and alcohol consumption are known life style factors contributing to gastrointestinal carcinogenesis. Genetic variations in carcinogen handling may affect cancer risk. The multidrug resistance 1(MDR1/ABCB1) gene encodes the transport protein P-glycoprotein (a phase III xenobiotic transporter). P-glycoprotein is present in the intestinal mucosal lining and restricts absorption...
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