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Article

A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.

PloS one - 1 Jan 2012

Campa Daniele, Sainz Juan, Pardini Barbara, Vodickova Ludmila, Naccarati Alessio, Rudolph Anja, Novotny Jan, Försti Asta, Buch Stephan, von Schönfels Witigo, Schafmayer Clemens, Völzke Henry, Hoffmeister Michael, Frank Bernd, Barale Roberto, Hemminki Kari, Hampe Jochen, Chang-Claude Jenny, Brenner Hermann, Vodicka Pavel, Canzian Federico

Abstract excerpt

ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performed to select 28...

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Source

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Identifiers

PMID: 22396794
DOI: 10.1371/journal.pone.0032784
PMCID: PMC3292569

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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