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Article

Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study.

BMC cancer - 28 Dec 2017

Falkowski Sabrina, Woillard Jean-Baptiste, Postil Deborah, Tubiana-Mathieu Nicole, Terrebonne Eric, Pariente Antoine, Smith Denis, Guimbaud Rosine, Thalamas Claire, Rouguieg-Malki Koukeb, Marquet Pierre, Picard Nicolas

Abstract excerpt

BACKGROUND: Associations between polymorphisms of UDP-glucuronosyltransferases (UGTs) or efflux transporters (e.g., P-glycoprotein and MRP2) and different types of cancer have been described, whereas the role of influx transporters (e.g. OATP1B1 and OATP2B1) has been seldom explored. The GenColon study investigated potential associations between variant alleles of UGTs, efflux and influx transporters and CRC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29282011
DOI: 10.1186/s12885-017-3728-0
PMCID: PMC5745594

Genes

ABCB1
ABCC2

Provenance

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