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Article

Multifunctional specificity of the protein C/activated protein C Gla domain.

The Journal of biological chemistry - 29 Sept 2006

Preston Roger J S, Ajzner Eva, Razzari Cristina, Karageorgi Stalo, Dua Sonia, Dahlbäck Björn, Lane David A

Abstract excerpt

Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein C/APC Gla domain is implicated in both interactions. We sought to identify how the protein C Gla domain enables specific protein-protein interactions in addition to its conserved role in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16867987
DOI: 10.1074/jbc.M604966200

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multifunctional specificity of the protein C/activated protein C Gla domain.PMID 16867987Read ↗

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