Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The thrombin mutant Trp215Ala/Glu217Ala induces cytoprotective signaling in endothelial cells by cleavage of Arg46 of protease-activated receptor 1.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2026

Biswas Indranil, Rezaie Alireza R

Abstract excerpt

BACKGROUND: The thrombin mutant W215A/E217A (WE-thrombin) is currently undergoing clinical trials to assess its therapeutic potential as an antithrombotic and cytoprotective drug. Mechanistically, it is thought that WE-thrombin exerts its protective effects indirectly through thrombomodulin (TM)-dependent activation of protein C (APC). APC exerts protective effects by both enzymatically inactivating procoagulant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoprotection
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Protein C

Share to Proteolysis

Share to Receptor, PAR-1

Share to Thrombin

Share to Thrombomodulin

Source

Open in PubMed Open full text

Identifiers

PMID: 41482217
DOI: 10.1016/j.jtha.2025.11.034
PMCID: PMC12790757

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The thrombin mutant Trp215Ala/Glu217Ala induces cytoprotective signaling in endothelial cells by cleavage of Arg46 of protease-activated receptor 1.PMID 41482217Read ↗

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3Semantic proximity Read ↗

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR1 or protein C.Semantic proximity Read ↗

Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand.Semantic proximity Read ↗

Biased agonism of protease-activated receptor-1 regulates thromboinflammation in murine sickle cell diseaseSemantic proximity Read ↗

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.Semantic proximity Read ↗

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.Semantic proximity Read ↗

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.Semantic proximity Read ↗

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.Semantic proximity Read ↗

Protease-Activated Receptor 1 as an Endogenous Model of Peptidergic Gαq-Gα12-Biased G Protein SignalingSemantic proximity Read ↗

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Semantic proximity Read ↗

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.Semantic proximity Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.