Article
The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991
Forsgren S, Dahl U, Söderström A, Holmberg D, Matsunaga T
Abstract excerpt
The mechanisms contributing to the development of autoimmune insulin-dependent diabetes mellitus have been analyzed in allophenic mouse chimeras of the NOD in equilibrium with C57BL/6 strain combination (where NOD is nonobese diabetic). Occurrence of lymphoid cell infiltration (insulitis) in panc...
Topics
- Animals
- Autoimmune Diseases
- Chimera
- Crosses, Genetic
- Diabetes Mellitus, Type 1
- Female
- Lymph Nodes
- Major Histocompatibility Complex
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Pancreas
- Pancreatic Diseases
- Phenotype