Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991

Forsgren S, Dahl U, Söderström A, Holmberg D, Matsunaga T

Abstract excerpt

The mechanisms contributing to the development of autoimmune insulin-dependent diabetes mellitus have been analyzed in allophenic mouse chimeras of the NOD in equilibrium with C57BL/6 strain combination (where NOD is nonobese diabetic). Occurrence of lymphoid cell infiltration (insulitis) in pancreatic islets was observed in the majority of such chimeras. The development of insulitis was found to correlate with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Major Histocompatibility Complex

Share to Mice, Inbred C57BL

Share to Phenotype

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 1924397
DOI: 10.1073/pnas.88.20.9335
PMCID: PMC52709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras.PMID 1924397Read ↗

THE NOD MOUSE: A Model of Immune DysregulationSemantic proximity Read ↗

NOD mice and autoimmunity.Semantic proximity Read ↗

B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.Semantic proximity Read ↗

Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice.Semantic proximity Read ↗

Specific destruction of islet transplants in NOD<-->C57BL/6 and NOD<-->C3H/Tif embryo aggregation chimeras irrespective of allelic differences in beta-cell antigens.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD MouseSemantic proximity Read ↗

A single recessive non-MHC diabetogenic gene determines the development of insulitis in the presence of an MHC-linked diabetogenic gene in NOD mice.Semantic proximity Read ↗

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.Semantic proximity Read ↗

NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.Semantic proximity Read ↗

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.Semantic proximity Read ↗

A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.