Article
The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Prochazka M, Gaskins H R, Shultz L D, Leiter E H
Abstract excerpt
Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block in T- and B-lymphocyte development. An unusually high incidence of spontaneous thymic lymphoma development was observed after transfer of this mutation from the C.B-17 congenic strain background onto the diabetes-susceptible nonobese diabetic (NOD) background. Thymomagenesis in the NOD-scid/scid mouse was associated with...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- DNA, Neoplasm
- Female
- Immunologic Deficiency Syndromes
- Leukemia Virus, Murine
- Lymphoma
- Male