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Article

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992

Prochazka M, Gaskins H R, Shultz L D, Leiter E H

Abstract excerpt

Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block in T- and B-lymphocyte development. An unusually high incidence of spontaneous thymic lymphoma development was observed after transfer of this mutation from the C.B-17 congenic strain background onto the diabetes-susceptible nonobese diabetic (NOD) background. Thymomagenesis in the NOD-scid/scid mouse was associated with...

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Identifiers

PMID: 1373493
DOI: 10.1073/pnas.89.8.3290
PMCID: PMC48852

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