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Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse

1 Oct 2004

Abstract excerpt

B-cells are important in the development of type 1 diabetes, but their role is not completely defined. Although B-cells produce autoantibodies, these are not thought to be pathogenic; however, their antigen-presenting function is postulated to be critical. To examine the relative importance of these functions of B-cells, we have generated nonobese diabetic (NOD) B-cell-deficient mice that express a transgene...

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PMID: 15448087
DOI: 10.2337/diabetes.53.10.2581

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