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Article

Generation of cytotoxicity against hepatitis delta virus genotypes and quasispecies by epitope modification.

Journal of hepatology - 1 Apr 2009

Huang Yi-Hsiang, Wu Jaw-Ching, Peng Wei-Li, Huo Teh-Ia, Shih Hsuan-Hui, Lan Keng-Hsin, Su Chien-Wei, Lee Shou-Dong

Abstract excerpt

BACKGROUND/AIMS: Quasispecies are likely responsible for virus escape from host immune surveillance. The aim of this study was to enhance the immune response against varied sequences within the HDV quasispecies in an attempt to control chronic delta hepatitis. METHODS: The HLA-A2 restricted peptides spanning aa 43-51 of HDAg and three variant peptides bearing single amino acid substitutions were synthesized....

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Share to CD8-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-A2 Antigen

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Source

Identifiers

PMID: 19243853
DOI: 10.1016/j.jhep.2008.11.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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