Article
Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1999
Chang K M, Gruener N H, Southwood S, Sidney J, Pape G R, Chisari F V, Sette A
Abstract excerpt
The inverse relationship between peripheral blood CTL responsiveness to multiple hepatitis C virus (HCV) epitopes and viral titer in patients with persistent HCV infection suggests that enhancement of the CTL response might result in viral clearance. Since several HLA-A2-restricted HCV CTL epitop...
Topics
- Acute Disease
- Adult
- Alleles
- Cytotoxicity Tests, Immunologic
- Epitopes, T-Lymphocyte
- Female
- HLA-A3 Antigen
- HLA-B7 Antigen
- Hepacivirus
- Hepatitis C
- Hepatitis C, Chronic
- Humans
- Male
- Middle Aged
- Peptide Fragments
- T-Lymphocytes, Cytotoxic