Article
A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice.
BMC infectious diseases - 5 Nov 2019
Dawood Reham M, Moustafa Rehab I, Abdelhafez Tawfeek H, El-Shenawy Reem, El-Abd Yasmine, Bader El Din Noha G, Dubuisson Jean, El Awady Mostafa K
Abstract excerpt
BACKGROUND: Although DAAs hold promise to significantly reduce rates of chronic HCV infections, its eradication still requires development of an effective vaccine. Prolonged T cell responses and cross neutralizing antibodies are ideal for vaccination against the infection. We aimed to design and synthesize a 6 multi epitope peptide vaccine candidate and provide evidence for production of extended cellular and...
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