Article
Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection.
Journal of translational medicine - 7 Oct 2016
Tischer Sabine, Geyeregger René, Kwoczek Julian, Heim Albert, Figueiredo Constanca, Blasczyk Rainer, Maecker-Kolhoff Britta, Eiz-Vesper Britta
Abstract excerpt
BACKGROUND: Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infection, which is hampered by delayed immune reconstitution and medical immunosuppression after HSCT. Protective immunity may be conferred by adoptive transfer of HAdV-specific T cells. For...
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