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Article

Amygdala protein kinase C epsilon controls alcohol consumption.

Genes, brain, and behavior - 1 Jul 2009

Lesscher H M B, Wallace M J, Zeng L, Wang V, Deitchman J K, McMahon T, Messing R O, Newton P M

Abstract excerpt

Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCepsilon) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCepsilon signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCepsilon in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice...

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Source

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Identifiers

PMID: 19243450
DOI: 10.1111/j.1601-183X.2009.00485.x
PMCID: PMC2714877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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