Article
Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.
Biological psychiatry - 15 May 2015
Repunte-Canonigo Vez, Herman Melissa, Kawamura Tomoya, Kranzler Henry R, Sherva Richard, Gelernter Joel, Farrer Lindsay A, Roberto Marisa, Sanna Pietro Paolo
Abstract excerpt
BACKGROUND: The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates small GTPases of the Ras family. METHODS: We assessed alcohol-related behaviors including alcohol sensitivity, dependent and nondependent drinking, and basal and alcohol-induced gamma-aminobutyric acid (GABA) release in the central nucleus of the amygdala (CeA) in Nf1 heterozygous null mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.