Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes.

doi:10.1111/adb.13388

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Article

Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes.

Addiction biology - 1 Mar 2024

Dugan Michael P, Maiya Rajani, Fleischer Caleb, Bajo Michal, Snyder Angela E, Koduri Ashwin, Srinivasan Sathvik, Roberto Marisa, Messing Robert O

Abstract excerpt

Protein kinase C epsilon (PKCε) regulates behavioural responses to ethanol and plays a role in anxiety-like behaviour, but knowledge is limited on downstream substrates of PKCε that contribute to these behaviours. We recently identified brain-specific serine/threonine-protein kinase 1 (BRSK1) as a substrate of PKCε. Here, we test the hypothesis that BRSK1 mediates responses to ethanol and anxiety-like behaviours...

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PMID: 38497285
DOI: 10.1111/adb.13388
PMCID: PMC10950061

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