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Article

Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2002

Choi Doo-Sup, Wang Dan, Dadgar Jahan, Chang Wesley S, Messing Robert O

Abstract excerpt

Conventional gene targeting is a powerful tool to study the influence of specific genes on behavior. However, conclusions relevant for adult animals are limited by consequences of gene loss during development. Mice lacking protein kinase C epsilon (PKCepsilon) consume less alcohol and show greater acute sensitivity to alcohol than do wild-type mice. There are no selective inhibitors of PKCepsilon that can be...

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PMID: 12427847
PMCID: PMC6757853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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