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Article

The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.

Nature neuroscience - 1 Aug 2004

Choi Doo-Sup, Cascini Maria-Grazia, Mailliard William, Young Hannah, Paredes Peter, McMahon Thomas, Diamond Ivan, Bonci Antonello, Messing Robert O

Abstract excerpt

Adenosine is an important mediator of ethanol intoxication. In vitro, ethanol stimulates adenosine signaling by inhibiting the type 1 equilibrative nucleoside transporter (ENT1), whereas chronic ethanol exposure downregulates ENT1. It is not known, however, whether ENT1 is important for ethanol intoxication or consumption in vivo. Here we report that ENT1-null mice show reduced hypnotic and ataxic responses to...

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PMID: 15258586
DOI: 10.1038/nn1288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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