Article
Polymorphic variants of antioxidative defense enzymes and their gene-gene epistatic interactions in systemic lupus erythematode patients.
Clinical rheumatology - 1 Sept 2017
Jevtovic Stoimenov Tatjana, Despotovic Milena, Stojanovic Sonja, Basic Jelena, Pavlovic Dušica
Abstract excerpt
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which pathogenesis oxidative stress has an important role. Single nucleotide polymorphisms (SNPs) in the genes that code enzymes involved in the antioxidative defense are possible factors that are responsible for their decreased activity of antioxidative defense enzymes. Thus, the aim of the study was to examine association of SNPs in these...
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