Article
Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.
Clinical rheumatology - 1 Sept 2021
de Oliveira Marco Aurélio Almeida, Mallmann Neila Hiraishi, de Souza Giselle Katiane Bonfim Bacellar, de Jesus Bacha Thiago, Lima Emerson Silva, de Lima Domingos Sávio Nunes, de Souza Passos Luiz Fernando, de Souza Gonçalves Marilda, de Moura Neto José Pereira
Abstract excerpt
OBJECTIVE: To investigate the frequency of glutathione S-transferase (GST), catalase, and SOD2 genetic polymorphisms and their correlation with SLE. METHODS: A total of 290 females (patients = 151; controls= 139) were recruited. Multiplex PCR was performed for genotyping GSTM1 and GSTT1 genes, whereas real-time qPCR was used for determination of SNPs: CAT C262T, SOD2 C47T, GSTP1 A313G and GSTP1 IVS6 -C16T....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.