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Article

Dimerization is responsible for the structural stability of human sulfotransferase 1A1.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2009

Lu Lu-Yi, Chiang Han-Ping, Chen Wei-Ti, Yang Yuh-Shyong

Abstract excerpt

Cytosolic sulfotransferases (SULTs) are responsible for the metabolism of a variety of drugs, xenobiotics, and endogenous compounds. Most cytosolic SULTs are found to be homodimers. However, transformation between monomeric and dimeric SULTs can be achieved by a single amino acid mutation. The importance of quaternary structure for cytosolic sulfotransferase was investigated using recombinant human SULT1A1, a...

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PMID: 19237513
DOI: 10.1124/dmd.108.025395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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