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Article

Genetic diversity and function in the human cytosolic sulfotransferases.

The pharmacogenomics journal - 1 Apr 2007

Hildebrandt M A T, Carrington D P, Thomae B A, Eckloff B W, Schaid D J, Yee V C, Weinshilboum R M, Wieben E D

Abstract excerpt

Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining insight into how these substitutions alter function is a step toward acquiring predictability. In this study, we incorporated gene resequencing, functional genomics, amino-acid characterization and crystal structure analysis for the cytosolic sulfotransferases...

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Source

Identifiers

PMID: 16801938
DOI: 10.1038/sj.tpj.6500404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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