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Article

The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology - 1 May 2009

Luckey Stephen W, Walker Lori A, Smyth Tyson, Mansoori Jason, Messmer-Kratzsch Antke, Rosenzweig Anthony, Olson Eric N, Leinwand Leslie A

Abstract excerpt

Mutations in cardiac troponin T (TnT) are a cause of familial hypertrophic cardiomyopathy (FHC). Transgenic mice expressing a missense mutation (R92Q) or a splice site donor mutation (Trunc) in the cardiac TnT gene have mutation-specific phenotypes but mice of both models have smaller hearts compared to wild type and exhibit hemodynamic dysfunction. Because growth-related signaling pathways in the hearts of mice...

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Share to Cardiomyopathy, Hypertrophic, Familial
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 19233194
DOI: 10.1016/j.yjmcc.2009.02.010
PMCID: PMC2701230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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