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Article

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.

Circulation - 8 Apr 2008

Tsoutsman Tatiana, Kelly Matthew, Ng Dominic C H, Tan Ju-En, Tu Emily, Lam Lien, Bogoyevitch Marie A, Seidman Christine E, Seidman J G, Semsarian Christopher

Abstract excerpt

BACKGROUND: Familial hypertrophic cardiomyopathy (FHC) is characterized by genetic and clinical heterogeneity. Five percent of FHC families have 2 FHC-causing mutations, which results in earlier disease onset, increased cardiac dysfunction, and a higher incidence of sudden death events. These observations suggest a relationship between the number of gene mutations and phenotype severity in FHC. METHODS AND...

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Share to Calcium Signaling
Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic, Familial

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Share to STAT3 Transcription Factor

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Source

Identifiers

PMID: 18362229
DOI: 10.1161/CIRCULATIONAHA.107.755777

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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