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Article

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.

The Journal of biological chemistry - 21 Jun 2002

Matsui Takashi, Li Ling, Wu Justina C, Cook Stuart A, Nagoshi Tomohisa, Picard Michael H, Liao Ronglih, Rosenzweig Anthony

Abstract excerpt

The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address this issue, we generated transgenic mice (TG+) with cardiac-specific expression of a constitutively active mutant of Akt (myr-Akt) driven by the myosin heavy chain-alpha promoter. Three TG+ founders (9-19 weeks) died suddenly with...

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Identifiers

PMID: 11943770
DOI: 10.1074/jbc.M200347200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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