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Article

p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2013

Passariello Catherine L, Gayanilo Marjorie, Kritzer Michael D, Thakur Hrishikesh, Cozacov Zoharit, Rusconi Francesca, Wieczorek David, Sanders Michael, Li Jinliang, Kapiloff Michael S

Abstract excerpt

Myocardial interstitial fibrosis is an important contributor to the development of heart failure. Type 3 p90 ribosomal S6 kinase (RSK3) was recently shown to be required for concentric myocyte hypertrophy under in vivo pathological conditions. However, the role of RSK family members in myocardial fibrosis remains uninvestigated. Transgenic expression of α-tropomyosin containing a Glu180Gly mutation (TM180) in...

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Identifiers

PMID: 23913705
DOI: 10.1152/ajpheart.00237.2013
PMCID: PMC3798750

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