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Article

Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2003

McMullen Julie R, Shioi Tetsuo, Zhang Li, Tarnavski Oleg, Sherwood Megan C, Kang Peter M, Izumo Seigo

Abstract excerpt

An unresolved question in cardiac biology is whether distinct signaling pathways are responsible for the development of pathological and physiological cardiac hypertrophy in the adult. Physiological hypertrophy is characterized by a normal organization of cardiac structure and normal or enhanced...

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Identifiers

PMID: 14507992
DOI: 10.1073/pnas.1934654100
PMCID: PMC218762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14507992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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