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Article

Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling

9 Jun 2006

Abstract excerpt

Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in many species, from rodents to humans, although its mechanisms of action are incompletely understood. Transcript profiling of hearts from a genetic model of cardiac hypertrophy revealed dramatic upregulation of myostatin, not previously recognized to play a role in the heart. Here we show that myostatin abrogates the...

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PMID: 16763166
DOI: 10.1161/01.res.0000231290.45676.d4

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