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Article

PIKfyve-dependent regulation of the Cl- channel ClC-2.

Biochemical and biophysical research communications - 10 Apr 2009

Klaus Fabian, Laufer Jörg, Czarkowski Kamil, Strutz-Seebohm Nathalie, Seebohm Guiscard, Lang Florian

Abstract excerpt

The widely expressed chloride channel ClC-2 is stimulated by the serum and glucocorticoid inducible kinase SGK1. The SGK1-dependent regulation of several carriers involves the mammalian phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3). The present experiments explored whether SGK1-dependent regulation of ClC-2 similarly involves PIKfyve. The conductance of Xenopus oocytes is increased more than...

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Source

Identifiers

PMID: 19232516
DOI: 10.1016/j.bbrc.2009.02.053

Genes

SGK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PIKfyve-dependent regulation of the Cl- channel ClC-2.PMID 19232516Read ↗

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