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Article

Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve.

Neurochemistry international - 1 Jan 2000

Klaus Fabian, Gehring Eva-Maria, Zürn Agathe, Laufer Joerg, Lindner Ricco, Strutz-Seebohm Nathalie, Tavaré Jeremy M, Rothstein Jeffrey D, Boehmer Christoph, Palmada Monica, Gruner Ivonne, Lang Undine E, Seebohm Guiscard, Lang Florian

Abstract excerpt

The Na(+), glutamate cotransporter EAAT3 is expressed in a wide variety of tissues. It accomplishes transepithelial transport and the cellular uptake of acidic amino acids. Regulation of EAAT3 activity involves a signaling cascade including the phosphatidylinositol-3 (PI3)-kinase, the phosphoinositide dependent kinase PDK1, and the serum and glucocorticoid inducible kinase SGK1. Targets of SGK1include the...

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Source

Identifiers

PMID: 19418632
DOI: 10.1016/j.neuint.2009.01.002

Genes

SGK1
PDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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