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Article

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2012

Pacheco-Alvarez Diana, Vázquez Norma, Castañeda-Bueno María, de-Los-Heros Paola, Cortes-González César, Moreno Erika, Meade Patricia, Bobadilla Norma A, Gamba Gerardo

Abstract excerpt

The serine/threonine with no lysine kinase 3 (WNK3) modulates the activity of the electroneutral cation-coupled chloride cotransporters (CCC) to promote Cl(-) influx and prevent Cl(-) efflux, thus fitting the profile for a putative "Cl(-)-sensing kinase". The Ste20-type kinases, SPAK/OSR1, become phosphorylated in response to reduction in intracellular chloride concentration and regulate the activity of NKCC1....

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Identifiers

PMID: 22415098
DOI: 10.1159/000337610

Genes

WNK3
OSR1

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WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.PMID 22415098Read ↗

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Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.Semantic proximity Read ↗

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity.Semantic proximity Read ↗

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Semantic proximity Read ↗

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.Semantic proximity Read ↗

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivoSemantic proximity Read ↗

Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Semantic proximity Read ↗

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).Semantic proximity Read ↗

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.Semantic proximity Read ↗

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Semantic proximity Read ↗

The evolving concepts of KS-WNK1 effect on NCC activity.Semantic proximity Read ↗

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