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Article

Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2006

Maier Gottlieb, Palmada Monica, Rajamanickam Jeyaganesh, Shumilina Ekaterina, Böhmer Christoph, Lang Florian

Abstract excerpt

Human ether-a-go-go (HERG) channels participate in the repolarization of the cardiac action potential. Loss of function mutations of HERG lead to delayed cardiac repolarization reflected by prolonged QT interval. HERG channels are regulated through a signaling cascade involving phosphatidylinositol 3 (PI3) kinase. Downstream targets of PI3 kinase include the serum and glucocorticoid inducible kinase (SGK) and...

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Identifiers

PMID: 17167223
DOI: 10.1159/000097666

Genes

SGK3
SGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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