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Article

ClC-3 is required for LPA-activated Cl− current activity and fibroblast-to-myofibroblast differentiation

13 Dec 2007

Abstract excerpt

To determine the effects of chloride channel 3 (ClC-3) knockdown and overexpression on lysophosphatidic acid (LPA)- and volume-regulated anion channel Cl(-) currents (I(Cl,LPA) and I(Cl,VRAC), respectively), cell differentiation, and cell volume regulation, a short hairpin RNA (shRNA) expression system based on a mouse U6 promoter was used to knock down ClC-3 in human corneal keratocytes and human fetal lung...

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Identifiers

PMID: 18077605
DOI: 10.1152/ajpcell.00291.2007

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