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Article

PIKfyve in the SGK1 mediated regulation of the creatine transporter SLC6A8.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2007

Strutz-Seebohm Nathalie, Shojaiefard Manzar, Christie David, Tavare Jeremy, Seebohm Guiscard, Lang Florian

Abstract excerpt

The Na(+),Cl(-),creatine transporter CreaT (SLC6A8) mediates concentrative cellular uptake of creatine into a wide variety of cells. Previous observations disclosed that SLC6A8 transport activity is enhanced by mammalian target of rapamycin (mTOR) at least partially through the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3. As SLC6A8 does not contain a putative SGK consensus motif, the...

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Source

Identifiers

PMID: 17982255
DOI: 10.1159/000110433

Genes

SGK1
SGK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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