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Article

The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro.

EMBO reports - 1 Jul 2003

Kim Sahn-Ho, Han Seungil, You Young-Hyun, Chen David J, Campisi Judith

Abstract excerpt

Human TIN2 interacts with the telomeric-DNA-binding protein TRF1, suppresses telomere elongation in telomerase-positive cells, and may control telomere length by modulating telomere structure. To test the latter idea, we developed an in vitro assay, using biotinylated telomeric DNA probes and streptavidin-agarose, to quantify the ability of TRF1 and TIN2 to stimulate interactions of telomeric DNA tracts with each...

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Identifiers

PMID: 12835755
DOI: 10.1038/sj.embor.embor872
PMCID: PMC1326318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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