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Article

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

The Journal of biological chemistry - 3 Dec 2004

Liu Dan, O'Connor Matthew S, Qin Jun, Songyang Zhou

Abstract excerpt

In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere biology. They interact with several other telomere regulators including TIN2, PTOP, POT1, and RAP1 to ensure proper maintenance of telomeres. TRF1 and TRF2 are believed to exert distinct functions. TRF1 forms a complex with TIN2, PTOP, and POT1 and regulates telomere length, whereas TRF2 mediates t-loop formation and end...

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Identifiers

PMID: 15383534
DOI: 10.1074/jbc.M409293200

Genes

POT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.PMID 15383534Read ↗

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1Semantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

TIN2 Mediates Functions of TRF2 at Human TelomeresSemantic proximity Read ↗

Telomere‐associated proteins: cross‐talk between telomere maintenance and telomere‐lengthening mechanismsSemantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrixSemantic proximity Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.Semantic proximity Read ↗

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human CellsSemantic proximity Read ↗

Importance of TRF1 for functional telomere structure.Semantic proximity Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

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