Article
Type 2 diabetes risk alleles are associated with reduced size at birth.
Diabetes - 1 Jun 2009
Freathy Rachel M, Bennett Amanda J, Ring Susan M, Shields Beverley, Groves Christopher J, Timpson Nicholas J, Weedon Michael N, Zeggini Eleftheria, Lindgren Cecilia M, Lango Hana, Perry John R B, Pouta Anneli, Ruokonen Aimo, Hyppönen Elina, Power Chris, Elliott Paul, Strachan David P, Järvelin Marjo-Riitta, Smith George Davey, McCarthy Mark I, Frayling Timothy M, Hattersley Andrew T
Abstract excerpt
OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype. The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion or action may predispose to type 2 diabetes and also reduce birth weight, since insulin is a key...
Topics
- Birth Weight
- Chromosome Mapping
- Cyclin-Dependent Kinase 5
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Homeodomain Proteins
- Humans
- Infant, Low Birth Weight