Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two decades since the fetal insulin hypothesis: what have we learned from genetics?

Diabetologia - 1 Apr 2021

Hughes Alice E, Hattersley Andrew T, Flanagan Sarah E, Freathy Rachel M

Abstract excerpt

In 1998 the fetal insulin hypothesis proposed that lower birthweight and adult-onset type 2 diabetes are two phenotypes of the same genotype. Since then, advances in research investigating the role of genetics affecting insulin secretion and action have furthered knowledge of fetal insulin-mediated growth and the biology of type 2 diabetes. In this review, we discuss the historical research context from which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth Weight
Share to Diabetes Mellitus, Type 2
Share to Fetal Growth Retardation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Infant, Low Birth Weight

Share to Insulin

Share to Insulin Resistance

Share to Insulin-Secreting Cells

Share to Mendelian Randomization Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 33569631
DOI: 10.1007/s00125-021-05386-7
PMCID: PMC7940336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two decades since the fetal insulin hypothesis: what have we learned from genetics?PMID 33569631Read ↗

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease.Semantic proximity Read ↗

Low birth weight, a risk factor for diseases in later life, is a surrogate of insulin resistance at birthSemantic proximity Read ↗

An unwelcome inheritance: childhood obesity after diabetes in pregnancySemantic proximity Read ↗

Fetal origins of adult diabetesSemantic proximity Read ↗

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?Semantic proximity Read ↗

Developmental aspects in the pathogenesis of type 2 diabetes.Semantic proximity Read ↗

Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.Semantic proximity Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

Fetal Origins of ObesitySemantic proximity Read ↗

The thrifty phenotype hypothesis.Semantic proximity Read ↗

Environmental and genetical aspects of the link between pregnancy, birth size, and type 2 diabetes.Semantic proximity Read ↗

Fetal determinants of type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.