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Article

Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.

Chinese medical journal - 20 Jul 2015

Sun Xiao-Fang, Xiao Xin-Hua, Zhang Zhen-Xin, Liu Ying, Xu Tao, Zhu Xi-Lin, Zhang Yun, Wu Xiao-Pan, Li Wen-Hui, Zhang Hua-Bing, Yu Miao

Abstract excerpt

BACKGROUND: Fetal insulin hypothesis was proposed that the association between low birth weight and type 2 diabetes is principally genetically mediated. The aim of this study was to investigate whether common variants in genes CDKAL1, HHEX, ADCY5, SRR, PTPRD that predisposed to type 2 diabetes were also associated with reduced birthweight in Chinese Han population. METHODS: Twelve single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 5

Share to Diabetes Mellitus, Type 2

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

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Source

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Identifiers

PMID: 26168825
DOI: 10.4103/0366-6999.160489
PMCID: PMC4717941

Genes

CDKAL1
SRR
ADCY5
HHEX
PTPRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.PMID 26168825Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.Semantic proximity Read ↗

Genetic origins of low birth weight.Semantic proximity Read ↗

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.Semantic proximity Read ↗

Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci.Semantic proximity Read ↗

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.Semantic proximity Read ↗

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.Semantic proximity Read ↗

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?Semantic proximity Read ↗

Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study.Semantic proximity Read ↗

Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians.Semantic proximity Read ↗

Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes.Semantic proximity Read ↗

Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.Semantic proximity Read ↗

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