Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

American journal of human genetics - 1 Jun 2007

Freathy Rachel M, Weedon Michael N, Bennett Amanda, Hypponen Elina, Relton Caroline L, Knight Beatrice, Shields Beverley, Parnell Kirstie S, Groves Christopher J, Ring Susan M, Pembrey Marcus E, Ben-Shlomo Yoav, Strachan David P, Power Chris, Jarvelin Marjo-Riitta, McCarthy Mark I, Davey Smith George, Hattersley Andrew T, Frayling Timothy M

Abstract excerpt

The role of genes in normal birth-weight variation is poorly understood, and it has been suggested that the genetic component of fetal growth is small. Type 2 diabetes genes may influence birth weight through maternal genotype, by increasing maternal glycemia in pregnancy, or through fetal genotype, by altering fetal insulin secretion. We aimed to assess the role of the recently described type 2 diabetes gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth Weight
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gestational Age

Share to Glucokinase

Share to Pregnancy

Share to Risk Factors

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 17503332
DOI: 10.1086/518517
PMCID: PMC1867102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.PMID 17503332Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.Semantic proximity Read ↗

Role of high-risk variants in the development of impaired glucose metabolism was modified by birth weight in Han Chinese.Semantic proximity Read ↗

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.Semantic proximity Read ↗

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?Semantic proximity Read ↗

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.Semantic proximity Read ↗

Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight.Semantic proximity Read ↗

Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study.Semantic proximity Read ↗

Genetic origins of low birth weight.Semantic proximity Read ↗

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.Semantic proximity Read ↗

A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.Semantic proximity Read ↗

Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.