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Article

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

Diabetes - 1 Oct 2009

Zhao Jianhua, Li Mingyao, Bradfield Jonathan P, Wang Kai, Zhang Haitao, Sleiman Patrick, Kim Cecilia E, Annaiah Kiran, Glaberson Wendy, Glessner Joseph T, Otieno F George, Thomas Kelly A, Garris Maria, Hou Cuiping, Frackelton Edward C, Chiavacci Rosetta M, Berkowitz Robert I, Hakonarson Hakon, Grant Struan F A

Abstract excerpt

OBJECTIVE: A number of studies have found that reduced birth weight is associated with type 2 diabetes later in life; however, the underlying mechanism for this correlation remains unresolved. Recently, association has been demonstrated between low birth weight and single nucleotide polymorphisms (SNPs) at the CDKAL1 and HHEX-IDE loci, regions that were previously implicated in the pathogenesis of type 2...

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Share to Birth Weight
Share to Cyclin-Dependent Kinase 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genetic Variation

Share to Infant, Low Birth Weight

Share to Infant, Newborn

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Source

Open in PubMed Open full text

Identifiers

PMID: 19592620
DOI: 10.2337/db09-0506
PMCID: PMC2750235

Genes

CDKAL1
HHEX
IDE
JAZF1
KCNJ11
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.PMID 19592620Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

Genetic origins of low birth weight.Semantic proximity Read ↗

Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.Semantic proximity Read ↗

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.Semantic proximity Read ↗

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.Semantic proximity Read ↗

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?Semantic proximity Read ↗

Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci.Semantic proximity Read ↗

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.Semantic proximity Read ↗

Polar Overdominance Inheritance of DLK1 Variants Is Associated with Birth Weight in a Sex-Specific Manner.Semantic proximity Read ↗

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.Semantic proximity Read ↗

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.Semantic proximity Read ↗

Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signallingSemantic proximity Read ↗

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