Article
HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Oct 2009
Winkler Christiane, Illig Thomas, Koczwara Kerstin, Bonifacio Ezio, Ziegler Anette-Gabriele
Abstract excerpt
CONTEXT: The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported. OBJECTIVE: Here, we examined the relationship between type 2 diabetes risk alleles and birth weight in a diabetic environment presented in children of...
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