Article
The complex relationship between BRCA1 and ERalpha in hereditary breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2009
Gorski Julia J, Kennedy Richard D, Hosey Alison M, Harkin D Paul
Abstract excerpt
Breast cancer 1 (BRCA1) was initially identified as one of the genes conferring genetic predisposition to both breast and ovarian cancer. One of the interesting aspects of BRCA1-linked cancers is the observed specificity for estrogen-responsive tissues such as breast and ovary. Recent advances in our understanding of BRCA1-linked breast cancers have revealed a complex relationship between BRCA1 and estrogen...
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